Microneedling with Salmon DNA Facial (PDRN)
Advanced Regenerative Treatment for Wrinkles, Texture, & Skin Repair
Microneedling with Salmon DNA Facial (PDRN) at Celebrity Skin Scottsdale is a clinically supported skin treatment that combines professional microneedling, purified polydeoxyribonucleotide (PDRN) derived from salmon DNA, and medical-grade LED Light Therapy to stimulate collagen production, support tissue repair, and improve fine lines, uneven texture, and skin tone.1-4
PDRN is a biologically active DNA fragment shown in clinical research to support cellular regeneration, fibroblast activity, and tissue repair pathways involved in skin healing and rejuvenation.1-3
Microneedling enhances the delivery of PDRN into the skin while simultaneously activating the body’s natural wound-healing response and collagen remodeling process.5-7
At Celebrity Skin, treatments are performed using the dual FDA-cleared Class II Skin Stylus Micro System, which creates controlled micro-channels to improve topical absorption and stimulate collagen induction.5-7 All Microneedling with Salmon DNA Facial (PDRN) treatments also include professional LED Light Therapy to enhance healing and results.
The Science Behind Microneedling with Salmon DNA (PDRN)
Polydeoxyribonucleotide (PDRN) consists of low-molecular-weight DNA fragments derived from salmon sperm cells and purified for medical and aesthetic use.
Clinical studies demonstrate that Microneedling with Salmon DNA (PDRN) supports:
- Fibroblast proliferation
- Angiogenesis and tissue regeneration
- Extracellular matrix remodeling
- Cellular repair signaling
These processes are directly involved in improving skin quality, elasticity, and resilience. 1-3
When delivered through microneedling, PDRN penetration is enhanced while collagen induction is simultaneously activated, producing a synergistic regenerative response. 4-7
What Microneedling with Salmon DNA (PDRN) Does for Your Skin
This advanced combination of using Salmon DNA (PDRN) with mircroneedling helps to:
- Improve fine lines and early wrinkles 2-4, 5-7
- Support collagen production and firmness 2-3, 5-7
- Refine uneven skin texture 4-7
- Improve post-inflammatory hyperpigmentation 1-2
- Strengthen the skin barrier 1-3
- Enhance hydration and resilience 2-4
This treatment is especially well suited for clients seeking gradual, long-term skin repair rather than aggressive correction.
Clinically Supported Active PDRN Components
The Salmon DNA Facial (PDRN) formulation contains purified bioactive components commonly used in regenerative and corrective skincare.
Polydeoxyribonucleotide (PDRN) Supports cellular regeneration and collagen remodeling 1-3
Hyaluronic Acid Supports hydration, elasticity, and barrier function 11
Peptides Support fibroblast signaling and skin remodeling 12
Antioxidants Help protect against oxidative stress 13
Supportive Nutrients Aid in post-procedure recovery and skin resilience
These components work together to promote healthier, stronger skin over time.
Results of Microneedling with Salmon DNA (PDRN)
With a customized treatment series, clients commonly experience:
- Smoother, more refined texture
- Reduced fine lines and wrinkles
- Improved firmness and elasticity
- More even skin tone
- Stronger skin barrier function
- Improved hydration and glow
- Long-term improvement in skin quality
Results continue to improve gradually as collagen remodeling progresses.
The Role of LED Light Therapy in Your Salmon DNA (PDRN) Microneedling Service
All treatments include professional LED Light Therapy using the FDA-cleared Celluma Series system.
Celluma devices hold multiple FDA clearances covering clinical indications such as acne, wrinkles, wound healing, pain management, and hair restoration.
Targeted wavelengths of blue, red, and near-infrared light help:
- Reduce inflammation
- Support collagen and elastin production
- Promote tissue repair
- Enhance post-treatment recovery
- Improve cellular function
This integrated approach helps maximize results while minimizing downtime.
Which Microneedling Treatment Is Right for Me?
Microneedling with Salmon DNA Facial (PDRN) & Medical-Grade LED Therapy
Best for long-term repair and strengthening:
- Fine lines and wrinkles
- Firmness
- Barrier support
- Skin quality improvement
- Typically does not require numbing.
Microneedling with Light Chemical Peel & Medical-Grade LED Therapy
Best for foundational correction:
- Acne scarring
- Hyperpigmentation
- Uneven texture
- Requires numbing one hour prior
Learn about our Microneedling with Light Chemical Peel & Medical-Grade LED Therapy here.
Microneedling with Exosomes & Medical-Grade LED Light Therapy
Best for faster regeneration and advanced correction:
- Acne scarring
- Enlarged pores
- Advanced texture damage
- Requires numbing one hour prior.
Learn about our Microneedling with Exosomes & Medical-Grade LED Therapy here.
Treatment Selection & Flexibility
A professional consultation helps guide the most appropriate approach for your skin goals. However, these microneedling treatments are intentionally designed to be interchangeable, with overlapping benefits that allow flexibility based on skin condition, timing, and treatment goals. With the exception of services that require numbing, most clients do not need to worry about selecting the “wrong” option in advance. Your provider will help determine the best treatment at the time of service to ensure optimal results.
Why These Treatments May Sound Similar
Microneedling, Salmon DNA (PDRN) Microneedling, and Exosome Microneedling all share core benefits because they are built on the same foundation—collagen induction and controlled skin repair.
While there is intentional overlap, combining microneedling with regenerative ingredients and medical-grade light therapy helps amplify results, accelerate healing, and improve visible outcomes more efficiently than microneedling alone.
Each added modality supports the skin through different mechanisms, allowing clients to see more noticeable improvements in texture, tone, and firmness in less time, while supporting long-term skin health.
Who Is Microneedling with Salmon DNA (PDRN) Best For?
This Microneedling with Salmon DNA (PDRN) treatment is ideal for clients seeking:
- Gradual wrinkle reduction
- Improved firmness and texture
- Strengthened skin barrier
- Long-term skin quality improvement
- Preventative anti-aging support
It is especially beneficial for clients focused on maintaining healthy, resilient skin over time.
FAQs – Microneedling with Salmon DNA (PDRN)
A regenerative treatment combining microneedling, PDRN infusion, and LED therapy to support skin repair and long-term rejuvenation. 1-7
No. This treatment is best for post-acne scarring and texture concerns, not active inflammatory acne. 4
Yes. When performed properly, microneedling-based treatments are widely used across skin tones. 6-7
Salmon DNA Microneedling is generally well tolerated and typically does not require numbing.
Most clients benefit from 3–6 treatments spaced 4–6 weeks apart. 2-6
Usually after 24 hours, once redness resolves.
Avoid sun exposure, sweating, exfoliants, retinoids, and aggressive skincare for 48–72 hours.
Yes. It may be combined with corrective facials, LED therapy, and other regenerative services.
Celebrity Skin uses the FDA-cleared Skin Stylus SteriLock MicroSystem. It is the only Microneedling device cleared at a 2.5mm depth. The Skin Styus SteriLock MicroSystem is the only patented 7 Step Safety System that prevents cross-contamination. It is the only Microneedling device with three different FDA-cleared 12 pin, 36 pin, and 36 pin HiLo technology
Microneedling devices not approved by the FDA have shown to have thick, dull, hooked or jagged needles, making them less precise and effective.
The Arizona State Board of Cosmetology does not regulate Microneedling, which means that anyone can perform this treatment without proper training or certification. Many practitioners are buying their Microneedling devices for $150 on Amazon and using non-sterile disposable needles made from powder-coated metals that can break off in your skin and their training consists of watching YouTube videos.
YouTube training does not teach clinical Microneedling techniques for safe, effective results specific to skin types, conditions and contraindications. Yes, these “Microneedling” treatments might be less expensive, but you will not get the result you are looking for. What is worse is you might wind up with hyperpigmentation, infection and/or scarring.
At Celebrity Skin we use specifically designed needles that pierce and glide across the skin delivering products at a prescribed depth. This prevents the skin from drying out during the procedure and delivers specific and essential nutrients to enhance results.
Our Native Hyaluronic Acid, Copper Peptide and Alpha Lipoic Acid serum works in conjunction with Microneedling treatments to deliver the active ingredients that work together to provide anti-inflammatory, hydrating, antioxidant, anti-aging, and wound support to the skin. These products are non-cytotoxic and free from synthetic molecules or preservatives.
At Celebrity Skin we use specifically designed needles that pierce and glide across the skin delivering products at a prescribed depth. This prevents the skin from drying out during the procedure and delivers specific and essential nutrients to enhance results.
Warning: Many practitioners are unaware that not all cosmeceuticals and serum formulations can be used when piercing the skin, no matter how effective they are generally. I cannot tell you how many times I have read and heard practitioners report they use Aquaphor/occlusives or various oils on clients’ skin directly following Microneedling.
- Active acne, rosacea, psoriasis, or eczema
- Herpes infection
- Sunburns
- Recent surgeries to areas to be treated
- Recent facial fillers or neurotoxins like Botox or Dysport (two weeks before or after)
- HIV/AIDS, Diabetes, Scleroderma, blood clotting problems
- Keloid or raised scars, warts or moles in a treatment area
- Avoid aspirin, ibuprofen and blood thinners to avoid excessive bleeding / bruising
- Avoid use of Retin-A products the evening prior to treatment
Immediately following Microneedling, the treatment area may be slightly swollen and feel warm and tight. It will look as though you have a moderate to severe sunburn. This intensity will subside after a couple of hours and “most” people will recover within the same day or within 24 hours. Avoid the sun, exercise and makeup until the following day. Post-treatment instructions will be provided.
People notice an immediate “glow” to their skin. Visible changes to the skin develop over the course of several days and weeks. Results continue to improve up to six months after treatment as collagen production continues.
Exosomes are small vesicles released by cells, including stem cells, that carry proteins, RNA,
and lipids for cell communication. Stem cell-derived exosomes inherit therapeutic properties like
regeneration and anti-inflammation.
Stem Cells vs. Exosomes
Stem cells are living cells that can differentiate, while exosomes are non-living vesicles that act
as messengers between cells.
Benefits of Exosome Therapy
Exosome therapy offers advantages over stem cell therapy, such as easier storage, no immune
rejection, and fewer ethical concerns.
Skin-Rejuvenation
Lyophilized exosomes from stem cells promote skin regeneration, improving collagen
production, elasticity, and texture, reducing fine lines and wrinkles for a youthful appearance.
Wound Healing and Scar Reduction
Lyophilized exosomes accelerate tissue repair, helping with post-surgical recovery and reducing
scars from acne, burns, or other skin injuries.
Anti-inflammatory
Exosomes have anti-inflammatory effects, soothing conditions like acne, rosacea, or eczema, and
promoting a clearer complexion.
Hydration
Exosomes improve skin hydration by nourishing and repairing the moisture barrier, leading to
smoother, more radiant skin.
Yes! We offer a package of 3 Microneedling Treatments for only $795 ($245 in savings!)
- 3 Microneedling Treatments (FDA Cleared Skin Stylus Sterilock)
- 3 Chemical Peels or Microdermabrasion
- 3 Celluma FDA Cleared Phototherapy Treatments
- 3 Rhonda Allison Aftercare Products
✨ Ready to Get Microneedling with Salmon DNA (PDRN)? ✨
Schedule your service today and take the next step toward smoother, stronger, and more confident skin.
Clinical References
- Kim JY, et al. Clin Interv Aging. 2014. PDRN and tissue regeneration.1
- Park YJ, et al. Ann Dermatol. 2017. PDRN in skin rejuvenation.
- Guizzardi S, et al. Int J Mol Med. 2003. DNA fragments and fibroblast activity.
- Lee JH, et al. J Cosmet Dermatol. 2016. PDRN cosmetic applications.
- Aust MC, et al. Plast Reconstr Surg. 2008. Percutaneous collagen induction.
- Alam M, et al. JAMA Dermatol. 2014. Microneedling clinical trial.
- Fernandes D. Aesthetic Surg J. 2002. Collagen induction therapy.
- Celluma FDA Device Information.
- Avci P, et al. Semin Cutan Med Surg. 2013. Photobiomodulation.
- Chung H, et al. Ann Biomed Eng. 2012. Light therapy mechanisms.
- Papakonstantinou E, et al. Dermatoendocrinol. 2012. Hyaluronic acid.
- Robinson LR. Int J Cosmet Sci. 2008. Peptide signaling.
- Pullar JM, et al. Nutrients. 2017. Antioxidants and skin.
